Method for obtaining binding kinetic rate constants using fiber optic particle plasmon resonance (FOPPR) sensor
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United States of America Patent
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Nov 29, 2016
Grant Date -
Feb 20, 2014
app pub date -
Oct 25, 2013
filing date -
Nov 14, 2011
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Abstract
A method for obtaining the binding kinetic rate constants using fiber optic particle plasmon resonance (FOPPR) sensor, suitable for a test solution with two or more concentrations, which employs the following major steps: providing one FOPPR sensor instrument system, obtaining optical time-resolved signal intensities starting at the initial time to the steady state of the two or more regions, substituting the measured signal intensity values into the formula which is derived by using the pseudo-first order rate equation model. In addition, this method measures the temporal signal intensity evolution under static conditions as the samples are quickly loaded. As a result, unlike the conventional device where the sample is continuously infused, the method is able to measure the association and dissociation rate constants of which the upper bounds are not limited by the sample flow rate.
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