HBV polymerase mutants

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United States of America Patent

PATENT NO 9512412
SERIAL NO

14232082

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Abstract

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The present invention relates to polymerase HBV mutant polypeptides comprising a mutated polymerase domain which is functionally disrupted for polymerase activity and fusion proteins comprising such polymerase mutant polypeptide. The present invention also relates to a nucleic acid molecule and an expression vector for expressing said polymerase mutant polypeptide as well as a composition which can be used for eliciting an immune response to HBV with the goal of providing a protective or therapeutic effect against HBV infection.

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Patent Owner(s)

  • TRANSGENE S.A.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Marchand, Jean-Baptiste Obernai, FR 16 124
Martin, Perrine L'Isle D'Abeau, FR 11 24
Silvestre, Nathalie Ergersheim, FR 27 82

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