Regulatable promoter

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United States of America Patent

PATENT NO 9512432
APP PUB NO 20140242636A1
SERIAL NO

14350352

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Abstract

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A method of producing a protein of interest (POI) by culturing a recombinant eukaryotic cell line comprising an expression construct comprising a regulatable promoter and a nucleic acid molecule encoding a POI under the transcriptional control of said promoter, comprising the steps a) cultivating the cell line with a basal carbon source repressing the promoter, b) cultivating the cell line with a limited amount of a supplemental carbon source de-repressing the promoter to induce production of the POI at a transcription rate of at least 15% as compared to the native pGAP promoter, and c) producing and recovering the POI; and further an isolated regulatable promoter and a respective expression system.

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Patent Owner(s)

Patent OwnerAddress
LONZA LTD3930 VISP

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gasser, Brigitte Vienna, AT 22 28
Klein, Joachim Visp, CH 23 189
Mattanovich, Diethard Vienna, AT 30 40
Maurer, Michael Vienna, AT 55 622
Prielhofer, Roland Vienna, AT 9 17
Wenger, Jana Visp, CH 4 11

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