Scalable fermentation process

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United States of America Patent

PATENT NO 9518095
SERIAL NO

14247097

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Abstract

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This invention provides a robust fermentation process for the expression of a capsid protein of a bacteriophage which is forming a VLP by self-assembly, wherein the process is scalable to a commercial production scale and wherein the expression rate of the capsid protein is controlled to obtain improved yield of soluble capsid protein. This is achieved by combining the advantages of fed-batch culture and of lactose induced expression systems with specific process parameters providing improved repression of the promoter during the growth phase and high plasmid retention throughout the process.

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Patent Owner(s)

Patent OwnerAddress
KUROS US LLC1209 ORANGE STREET CORPORATION TRUST CENTER WILMINGTON DE 19801

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Emmerling, Marcel Schlieren, CH 6 6
Hennecke, Frank Dietlikon, CH 15 77
Pfründer, Holger Zürich, CH 6 6
Rhiel, Martin Bonstetten, CH 6 6
Steiner, Philipp Schlieren, CH 55 556

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