Methods, compositions, and kits for detecting protein aggregates

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United States of America Patent

PATENT NO 9518296
APP PUB NO 20140134624A1
SERIAL NO

13975056

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Abstract

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The present teachings provide methods, compositions, and kits for detecting the presence of protein aggregates. In some embodiments, the protein aggregate is treated with a labeled precursor, and the labeled precursor is incorporated into the protein aggregate to form a labeled protein aggregate. The labeled protein aggregate is then measured, thus detecting the presence of the protein aggregate. In some embodiments, the labeled protein aggregate is detected by interaction of labeled precursors, for example by a proximity ligation assay.

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Patent Owner(s)

  • APPLIED BIOSYSTEMS INC.;APPLIED BIOSYSTEMS, LLC

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Guegler, Karl Menlo Park, US 82 183
Hennessy, Kevin San Mateo, US 18 171
Livak, Kenneth San Jose, US 5 3
Ruff, David San Francisco, US 43 621
Shannon, Mark San Francisco, US 19 394

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