Plurimodal release formulation of doxylamine and pyridoxine and/or metabolites or salts thereof
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United States of America Patent
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Dec 27, 2016
Grant Date -
Mar 3, 2016
app pub date -
Aug 28, 2015
filing date -
Aug 29, 2014
priority date (Note) -
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Abstract
A solid oral dosage form comprising a core comprising a doxylamine component and a pyridoxine component coated with an enteric coating is disclosed. The solid oral dosage form further comprises two active ingredient-containing coatings surrounding the enteric coating, the active ingredient-containing coatings being separated from one another by an intermediate coating, and one of the two active ingredient-containing coatings comprising a doxylamine component and being free of a pyridoxine component, and the other of the two active ingredient-containing coatings comprising a pyridoxine component and being free of doxylamine component. Uses of the solid oral dosage form for the alleviation of the symptoms of nausea and vomiting, for example in the case of nausea and vomiting of pregnancy (NVP), are also disclosed.
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Family
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