Humanized alpha-enolase specific antibodies and methods of uses in cancer therapy

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United States of America Patent

PATENT NO 9527922
APP PUB NO 20160185876A1
SERIAL NO

14588212

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Abstract

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A humanized antibody, or a binding fragment thereof, wherein the humanized antibody binds human ENO1 (GenBank: AAH50642.1), wherein the antibody comprises a light chain variable region (VL) domain comprising a CDR1 having the amino acid sequence LCDR1 (RASENIYSYLT; SEQ ID NO: 6) and a CDR2 having the amino acid sequence LCDR2 (NAKTLPE; SEQ ID NO: 7) and a CDR3 having the amino acid sequence LCDR3 (QHHYGTPYT; SEQ ID NO: 8) and an antibody heavy chain variable region (VH) domain comprising a CDR1 having the amino acid sequence HCDR1 (GYTFTSCVMN; SEQ ID NO: 3), a CDR2 having the amino acid sequence HCDR2 (YINPYNDGTKYNEKFKG; SEQ ID NO: 4) and a CDR3 having the amino acid sequence HCDR3 (EGFYYGNFDN; SEQ ID NO: 5), wherein framework regions in the light chain variable region (VL) domain and the heavy chain variable region (VH) domain comprise amino acid sequences from a human immunoglobulin.

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Patent Owner(s)

Patent OwnerAddress
NATIONAL HEALTH RESEARCH INSTITUTES35 KEYAN ROAD ZHUNAN TOWN 35053

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Li-Tzong Miaoli County, TW 9 64
Huang, Chao-Yang New Taipei, TW 19 66
Lai, Jiann-Shiun New Taipei, TW 27 114
Liu, Ko-Jiunn Miaoli County, TW 18 27
Lok, Ying-Yung New Taipei, TW 5 6
Shih, Neng-Yao Miaoli County, TW 12 27
Tsai, Shih-Chong New Taipei, TW 8 9
Tsai, Ya-Wei New Taipei, TW 3 2
Tseng, Shih-Chi New Taipei, TW 5 5
Wu, Chia-Cheng New Taipei, TW 32 30
Wu, Chung-Hsiun New Taipei, TW 9 59
Yuan, Ta-Tung New Taipei, TW 14 33

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