Use of cytokine-releasing, biodegradable particles in hyaluronic acid for the treatment of cartilage defects, in particular of osteoarthrosis

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United States of America Patent

PATENT NO 9539297
APP PUB NO 20130337074A1
SERIAL NO

13990643

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Abstract

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The present invention relates to a composition comprising, or consisting of 2-50 mg/ml hyaluronic acid, 0.1-500 mg/ml of biodegradable particles with an average mean particle diameter of 1 nm-500 μm, 1 pg/ml-10 μg/ml cytokines, where the concentrations specified are based in each case on the total volume (w/v) of the composition and where the cytokines are enclosed in the biodegradable particles, and to their use in the treatment of cartilage defects, for example traumatic cartilage defects or osteoarthrosis.

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Patent Owner(s)

  • CHARITE-UNIVERSITATSMEDIZIN BERLIN;CHARITE—UNIVERSITATSMEDIZIN BERLIN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Andreas, Kristin Berlin, DE 1 0
Ringe, Jochen Birkenwerder, DE 5 23
Sittinger, Michael Berlin, DE 12 271

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