Aldehyde-tagged immunoglobulin polypeptides and methods of use thereof

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United States of America Patent

PATENT NO 9540438
APP PUB NO 20120183566A1
SERIAL NO

13350676

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Abstract

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The present disclosure provides aldehyde-tagged immunoglobulin (Ig) polypeptides that can be converted by a formylglycine-generating enzyme to produce a 2-formylglycine (FGly)-modified Ig polypeptide. An FGly-modified Ig polypeptide can be covalently and site-specifically bound to a moiety of interest to provide an Ig conjugate. The disclosure also encompasses methods of production of such aldehyde-tagged Ig polypeptides, FGly-modified Ig polypeptides, and Ig conjugates, as well as methods of use of same.

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Patent Owner(s)

Patent OwnerAddress
REDWOOD BIOSCIENCE INC5703 HOLLIS STREET EMERYVILLE CA 94608

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Barfield, Robyn M Berkeley, US 19 157
Breidenbach, Mark Alan Oakland, US 4 65
deHart, Gregory W El Cerrito, US 11 55
Rabuka, David Oakland, US 57 343

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