Method for opening tight junctions

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United States of America Patent

PATENT NO 9540649
SERIAL NO

12682331

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Abstract

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The present invention is directed to a method and use of RNA interference (RNAi) for the transient, reversible and controlled opening of the tight junctions of the blood brain barrier and/or the blood retinal barrier. This method may be used in the treatment of many diseases and disorders which require the opening of the blood brain barrier and/or blood retinal barrier. Such methods generally involve the use of an RNAi-inducing agent, such as siRNA, miRNA, shRNA or an RNAi-inducing vector whose presence within a cell results in production of an siRNA or shRNA, targeting tight junction proteins to open the blood brain barrier and/or blood retinal barrier.

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Patent Owner(s)

Patent OwnerAddress
THE PROVOST FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLINCOLLEGE GREEN DUBLIN 2 DUBLIN IRELAND

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Campbell, Matthew Dublin, IE 65 301
Humphries, Peter Dublin, IE 22 101
Kiang, Anna-Sophia County Wicklow, IE 8 4

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