Controlled-release melatonin compositions and related methods
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United States of America Patent
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Jan 24, 2017
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app pub date -
Nov 16, 2015
filing date -
Jan 28, 2011
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Abstract
A method of treating a human subject in need of melatonin therapy includes administering to a human subject a compressed tablet comprising melatonin, citric acid, and a cellulosic polymer. The melatonin, citric acid, and cellulosic polymer combine after ingestion to form an acidic hydrogel that dissolves the melatonin and is effective to provide a first release dose of melatonin for assisting in inducement of sleep and a subsequent sustained release dose of melatonin for assisting in sustaining sleep while in the human subject's gastrointestinal tract.
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