Annexin II compositions

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United States of America Patent

PATENT NO 9555074
SERIAL NO

13878023

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention provides compositions and methods that involve the 36 kDa annexin II monomer, which has been identified as having immunostimulatory properties. Accordingly, in one aspect, the invention provides compositions that include at least one 36 kDa annexin II monomer or an immunomodulatory fragment thereof. In another aspect, the invention provides methods that include administering to a subject a composition that includes at least one 36 kDa annexin II monomer or an immunomodulatory fragment thereof. In another aspect, the invention provides methods that induce an in situ increase in the 36 kDa annexin II monomer by administering to a subject an amount of composition effective to induce localized hypoxia sufficient to cause a localized increase in annexin II.

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Patent Owner(s)

  • REGENTS OF THE UNIVERSITY OF MINNESOTA

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ohlfest, John R Minneapolis, US 10 41
Olin, Michael R New Brighton, US 4 13

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