Lung volume reduction therapy using crosslinked non-natural polymers

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United States of America Patent

PATENT NO 9561301
APP PUB NO 20150217020A1
SERIAL NO

14686306

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Abstract

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One aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant nucleophilic groups and a crosslinker comprising at least two pendant electrophilic groups. Another aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant electrophilic groups and a crosslinker comprising at least two pendant nucleophilic groups. Yet another aspect of the invention relates to a method for reducing lung volume in a patient comprising the step of administering a hydrogel composition as described herein. Further, hydrogels of the invention may be used to achieve pleurodesis, seal brochopleural fistulas, seal an air leak in a lung, achieve hemostasis, tissue sealing (e.g., blood vessels, internal organs), or any combination thereof. In certain embodiments, the compositions and methods described herein are intended for use in the treatment of patients with emphysema.

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Patent Owner(s)

Patent OwnerAddress
PULMONX700 CHESAPEAKE DRIVE REDWOOD CITY CA 94063

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ingenito, Edward P North Quincy, US 17 1248
Krom, James A Belmont, US 11 222
Schwarz, Alexander Brookline, US 166 4321
Tsai, Larry W Boston, US 9 136

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