Antisense oligonucleotide modulators of serotonin receptor 2C and uses thereof
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United States of America Patent
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Feb 14, 2017
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Nov 9, 2012
filing date -
Nov 10, 2011
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Abstract
The present invention provides, among other things, oligonucleotide modulators of human 5′-HT2C receptor (HTR2C) and improved methods and composition for treating HTR2C-related diseases, disorders or conditions based on such modulators. In particular, oligonucleotides modulators according to the invention target specific regions in the Exon V/Intron V junction of the human HTR2C pre-mRNA and drive expression of HTR2C Vb splice isoform, leading to increased generation of non-edited strong HTR2C receptor and enhanced serotonin receptor activity.
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