Polyvalent conjugate vaccine for cancer

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United States of America Patent

PATENT NO 9572875
APP PUB NO 20160250306A1
SERIAL NO

14872232

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Abstract

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This invention provides a polyvalent vaccine comprising at least two conjugated antigens selected from a group containing glycolipid antigen, polysaccharide antigen, mucin antigen, glycosylated mucin antigen and an appropriate adjuvant. This invention also provides a multivalent vaccine comprising at least two of the following: glycosylated MUC-1-32mer, Globo H, GM2, Ley, Tn(c), sTN(c), and TF(c). This invention provides the vaccine above, wherein the adjuvant is saponin-based adjuvant. This invention provides a method for inducing immune response in a subject comprising administering an effective amount of the vaccine above to the subject. Finally, this invention provides a method for treating cancer in a subject comprising administering an appropriate amount of the vaccine above to the subject.

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Patent Owner(s)

Patent OwnerAddress
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH1275 YORK AVENUE NEW YORK NY 10065

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Danishefsky, Samuel J Englewood, US 112 1071
Livingston, Philip O New York, US 24 291
Ragupathi, Govindaswami New York, US 22 232

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