Compositions for enhancing transport of molecules into cells
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United States of America Patent
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Feb 21, 2017
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app pub date -
Nov 5, 2008
filing date -
Apr 29, 2003
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Abstract
Compositions and methods for enhancing delivery of molecules, e.g. biological agents, into cells are described. The composition is a conjugate of the biological agent, preferably a nucleic acid analog having a substantially uncharged backbone, covalently linked to a peptide transporter moiety as described. Conjugation of the peptide transporter to a substantially uncharged nucleic acid analog, such as a morpholino oligomer, is also shown to enhance binding of the oligomer to its target sequence and enhance antisense activity.
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