Methods and compositions for treating malignant tumors associated with KRAS mutation

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United States of America Patent

PATENT NO 9580710
SERIAL NO

14979573

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Abstract

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This invention provides methods and compositions for preventing, treating or ameliorating one or more symptoms of a malignant tumor associated with KRAS mutation in a mammal in need thereof, by identifying a tumor cell in the mammal, the tumor cell comprising at least one of: (i) a mutation of the KRAS gene, and (ii) an aberrant expression level of KRAS protein; and administering to the mammal a therapeutically effective amount of a composition comprising one or more RNAi molecules that are active in reducing expression of GST-π.

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Patent Owner(s)

  • NITTO DENKO CORPORATION

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Adami, Roger Carlsbad, US 19 44
Liu, Jihua San Marcos, US 23 62
Majeti, Bharat San Diego, US 21 60
Minomi, Kenjirou Osaka, JP 25 72
Wang, Li San Diego, US 850 5963
Ying, Wenbin San Diego, US 69 400

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