P13K pathway mutations in cancer

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United States of America Patent

PATENT NO 9580750
APP PUB NO 20110059434A1
SERIAL NO

11920860

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Abstract

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Given the important role of protein kinases in pathways affecting cellular growth and invasion, we have analyzed 340 serine/threonine kinases for genetic mutations in colorectal cancers. Mutations in eight genes were identified, including three members of the phosphatidylinositol-3-kinase (PI3K) pathway; the alterations in the latter genes each occurred in different tumors and did not overlap with mutations in PIK3CA or other non-serine-threonine kinase (STK) members of the PI3K pathway, suggesting that mutations in any of these genes had equivalent tumorigenic effects. These data demonstrate that the PI3K pathway is a major target for mutational activation in colorectal cancers and provide new opportunities for therapeutic intervention.

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Patent Owner(s)

  • THE JOHNS HOPKINS UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bardelli, Alberto Turin, IT 20 77
Kinzler, Kenneth W Bel Air, US 281 4771
Lengauer, Christopher Noisy-le-Roi, FR 1 0
Parsons, Donald William Ellicott City, US 1 0
Samuels, Yardena Baltimore, US 11 64
Velculescu, Victor Dayton, US 54 615
Vogelstein, Bert Baltimore, US 323 6299
Wang, Tian-li Baltimore, US 6 240

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