Myeloperoxidase, a risk indicator for cardiovascular disease

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United States of America Patent

PATENT NO 9581597
SERIAL NO

15135757

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Diagnostic tests for characterizing an individual's risk of developing or having a cardiovascular disease. In one embodiment the present diagnostic test comprises determining the level of myeloperoxidase (MPO) activity in a bodily sample obtained from the individual or test subject. In another embodiment, the diagnostic test comprises determining the level of MPO mass in a bodily sample obtained from the test subject. In another embodiment, the diagnostic test comprises determining the level of one or more select MPO-generated oxidation products in a bodily sample obtained from the test subject. The select MPO-generated oxidation products are dityrosine, nitrotyrosine, methionine sulphoxide or an MPO-generated lipid peroxidation products. Levels of MPO activity, MPO mass, or the select MPO-generated oxidation product in bodily samples from the test subject are then compared to a predetermined value that is derived from measurements of MPO activity, MPO mass, or the select MPO-generated oxidation product in comparable bodily samples obtained from the general population or a select population of human subjects. Such comparison characterizes the test subject's risk of developing CVD.

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Patent Owner(s)

  • THE CLEVELAND CLINIC FOUNDATION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hazen, Stanley L Pepper Pike, US 68 227
Zhang, Renliang Cleveland, US 14 61

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