Defined media for expansion and maintenance of pluripotent stem cells

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United States of America Patent

PATENT NO 9593307
APP PUB NO 20160251615A1
SERIAL NO

15150349

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Abstract

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The present invention provides methods to promote the proliferation of undifferentiated pluripotent stem cells in defined media. Specifically, the invention provides a defined cell culture formulation for the culture, maintenance, and expansion of pluripotent stem cells, wherein culturing stem cells in the defined cell culture formulation maintains the pluripotency and karyotypic stability of the cells for at least 10 passages. Further disclosed is a cell population, grown under defined media conditions, that expresses OCT4, SOX2, NANOG, and FOXA2.

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Patent Owner(s)

  • JANSSEN BIOTECH, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Rezania, Alireza Horsham, US 108 9726

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