Inhibitors of atypical protein kinase C and their use in treating hedgehog pathway-dependent cancers

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United States of America Patent

PATENT NO 9597369
APP PUB NO 20150335702A1
SERIAL NO

14728916

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Abstract

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Methods and compositions are provided for modulating Hedgehog (Hh) pathway signaling in a cell. Aspects of the methods include methods for inhibiting Hh pathway-promoted cancer proliferation and/or metastasis that is promoted by Hh pathway signaling, methods for treating cancers promoted by Hh pathway signaling, and methods for screening candidate agents for the ability to treat a cancer promoted by Hh pathway signaling. In addition, reagents and kits thereof that find use in practicing the subject methods are provided.

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Patent Owner(s)

  • THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Atwood, Scott X Stanford, US 2 5
Oro, Anthony Stanford, US 4 10

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