Polyamine transporter selective compounds as anti-cancer agents
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United States of America Patent
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Mar 21, 2017
Grant Date -
Mar 17, 2016
app pub date -
Sep 23, 2015
filing date -
May 2, 2007
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Abstract
Several aromatic hydrocarbons di-substituted with a polyamine are described according to formulas selected from compounds 4, 7, 10, 15 and pharmaceutically acceptable salts thereof. The novel dimeric polyamines of the present invention demonstrate enhanced penetration into cells having an upregulated polyamine transport system, such as various types of cancer cells. The disclosed aromatic polyamine dimers provide highly efficient drugs for targeting cancer cells with active polyamine transporters.
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