Oral and/or buccal composition in the form of a thin film of a weakly soluble active ingredient, method of preparing same and use of same
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United States of America Patent
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Mar 28, 2017
Grant Date -
Dec 17, 2015
app pub date -
Dec 9, 2013
filing date -
Dec 10, 2012
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Abstract
The present invention relates to an oral and/or buccal composition in the form of a thin film of a pharmaceutically active ingredient weakly soluble in water and gastro-intestinal tract fluids, comprising particles of said active ingredient dispersed in a film-forming polymer, at least 50% by weight of the total weight of the active ingredient having a particle size distribution such that at least 90% of said particles have a size below 1000 nm, preferably less than 800 nm, and even more preferably less than 600 nm, and to the method of preparing that composition and the use thereof.
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