Intranasal insulin administration for the minimization of anesthesia-induced memory loss
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United States of America Patent
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Mar 28, 2017
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app pub date -
Mar 13, 2015
filing date -
Mar 13, 2014
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Abstract
Intranasal administration of insulin for a predetermined period prior to anesthesia significantly prevented anesthesia-induced tau hyperphosphorylation and cognitive impairment and enhanced brain insulin signaling in mice. Intranasal insulin thus provides a treatment for prevention of anesthesia-induced tau pathology and increased risk for tauopathies in surgical patients and may be administered to a subject prior to anesthesia, such as by administering several doses of intranasal insulin for several consecutive days prior to any anesthesia.
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