Method of generating linkage-specific di-and polyprotein probes

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United States of America Patent

PATENT NO 9605297
APP PUB NO 20160237471A1
SERIAL NO

15029519

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Abstract

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Deubiquitinating enzyme (DUB) probes are provided that resemble native diubiquitin (diUB) with a similar linkage size and that may contain a Michael acceptor for trapping the DUB active-site cysteine. For example, both K63- and K48-linked diubiquitin probes are generated using a facile chemical ligation method, utilizing the linker compound 3-(2-(bromomethyl)-1,3-dioxolan-2-yl)prop-2-en-1-amine. The diUb probes are capable of labelling DUBs from different families and may be employed to reveal intrinsic linkage specificities of DUBs.

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Patent OwnerAddress
UNIVERSITY OF DELAWAREOFFICE OF ECONOMIC INNOVATION & PARTNERSHIPS 591 COLLABORATION WAY SUITE 204 NEWARK DE 19713

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Li, Guorui Baltimore, US 3 14
Zhuang, Zhihao Wilmington, US 2 3

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