Antisense oligonucleotide directed removal of proteolytic cleavage sites from proteins

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 9611471
APP PUB NO 20130198877A1
SERIAL NO

13814203

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Abstract

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Described are means and methods for removing a proteolytic cleavage site from a protein, the method comprising providing a cell that expresses pre-mRNA encoding the protein with an anti-sense oligonucleotide that induces skipping of the exonic sequence that encodes the proteolytic cleavage site, and allowing translation of mRNA produced from the pre-mRNA.

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Patent Owner(s)

Patent OwnerAddress
ACADEMISCH ZIEKENHUIS LEIDEN H O D N LUMCALBINUSDREEF 2 LEIDEN 2333 ZA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Aartsma-Rus, Annemieke Hoofddorp, NL 32 1577
Evers, Melvin Maurice Utrecht, NL 9 23
Pepers, Barry Antonius Leiden, NL 6 23
Van, Ommen Garrit-Jan Boudewijn Amsterdam, NL 43 1951
van, Roon-Mom Wilhelmina M C Beverwijk, NL 3 12

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