Silica nanoparticles doped with multiple dyes featuring highly efficient energy transfer and tunable Stokes-shift
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United States of America Patent
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Apr 11, 2017
Grant Date -
Nov 28, 2013
app pub date -
Oct 13, 2011
filing date -
Oct 14, 2010
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Abstract
The present invention relates to silica nanoparticles comprising at least two dyes. Said dyes have a respective relationship of donor-acceptor couple in an energy transfer process and have a molar absorption coefficient ≧10,000 M−1 cm−1 for the considered spectral region, a fluorescence quantum yield ≧0.01, good overlap integral, according to the Förster theory, between said donor and said acceptor dye; said active compounds may be lipophilic or may present a functionality useful for the introduction of a trialkoxysilane moiety. The dyes provide an efficient energy transfer process. Said nanoparticles are useful as probes in the field of medicine, in particular therapy and diagnostics, more particularly in theranostics, and in the field of analytical chemistry.
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