Tricyclic compounds as inhibitors of immunosuppression mediated by tryptophan metabolization
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United States of America Patent
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Apr 11, 2017
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app pub date -
Mar 10, 2014
filing date -
Mar 14, 2013
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Abstract
Presently provided are inhibitors of IDO and TDO and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase and tryptophan 2,3 dioxygenase; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosuppression associated with an infectious disease.
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