Treatment of penetrative injury to the brain
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United States of America Patent
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Apr 25, 2017
Grant Date -
Oct 10, 2013
app pub date -
Aug 12, 2011
filing date -
Aug 12, 2010
priority date (Note) -
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Abstract
The invention provides methods of treatment or prophylaxis of damaging effects of penetrative injury to the brain or other part of the central nervous system. The methods are based in part on results in a rodent model of penetrative ballistic injury showing that an inhibitor of PDF-95 NMDAR interaction is effective in inhibiting neurological deficits resulting from such injury. The methods are useful for treating subjects having or at risk of penetrative brain injury, including subjects who have been shot in the head or at risk of such injury (e.g., military or law enforcement personnel).
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