DNA polymerases with increased substrate scope
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United States of America Patent
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Apr 25, 2017
Grant Date -
Sep 24, 2015
app pub date -
Aug 8, 2012
filing date -
Aug 8, 2012
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Abstract
The present invention relates to DNA polymerases displaying increased substrate scope such as improved reverse transcriptase and DNA polymerase activities, as well as improved activities for incorporating and extending modified nucleotides. In particular, the present invention relates to DNA polymerases derived from wild-type Thermus aquaticus (Taq) polymerase, comprising the mutations S515R, I638F, and M747K with regard to the wild-type amino acid sequence. The present invention further relates to nucleic acids coding for the DNA polymerases of the present invention, vectors containing said nucleic acids, host cells containing said vectors or nucleic acids, methods for the generation of DNA molecules using said DNA polymerases, kits containing said DNA polymerases, and uses thereof.
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