Dual delivery system for heterologous antigens
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United States of America Patent
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May 16, 2017
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Nov 13, 2014
app pub date -
Jul 25, 2014
filing date -
May 19, 2008
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Abstract
Provided herein are recombinant Listeria strains expressing a tumor-specific antigenic polypeptide and, optionally, an angiogenic polypeptide wherein a nucleic acid molecule encoding at least one of the polypeptides is operably integrated into the Listeria genome in an open reading frame with a nucleic acid sequence encoding a PEST-containing polypeptide, methods of preparing same, and methods of inducing an immune response, and treating, inhibiting, or suppressing cancer or tumors comprising administering same.
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