Process for preparing a pharmaceutical formulation of contrast agents

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United States of America Patent

PATENT NO 9655983
SERIAL NO

12918259

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention relates to a process for preparing a liquid pharmaceutical formulation containing a complex of macrocyclic chelate with a lanthanide and a mol/mol amount of free macrocyclic chelate of between 0.002% and 0.4%, advantageously between 0.02% and 0.3% and very advantageously between 0.025% and 0.25%, the macrocyclic chelate advantageously being chosen from DOTA, NOTA, DOTAGA, DO3A, BT-DO3A, HP-DO3A and PCTA, and is preferably DOTA, the said process comprising the following successive steps: b) preparation of a liquid pharmaceutical composition containing, firstly, the complex of macrocyclic chelate with a lanthanide, and, secondly, free macrocyclic chelate and/or free lanthanide; c) measurement in the pharmaceutical formulation obtained in step b) of the concentration of free macrocyclic chelate C ch1 and/or of free lanthanide C lan1; d) adjustment of C ch1 and/or of C lan1 so as to obtain C ch1=C tch1 and C lan1=0, wherein C t ch1 is the target concentration of free macrocyclic chelate in the final liquid pharmaceutical formulation.

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Patent Owner(s)

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GUERBET93420 VILLEPINTE

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Barbotin, Vincent Montmorency, FR 5 12
Bonnemain, Bruno Villeparisis, FR 10 94
Corot, Claire Lyons, FR 16 108
Meyer, Dominique La Rochelle, FR 32 287
Port, Marc Deuil la Barre, FR 33 226

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