Modulators of retinoid-related orphan receptor gamma

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United States of America Patent

PATENT NO 9657053
SERIAL NO

13766076

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Methods for modulating (inhibiting or stimulating) retinoid-related orphan receptor γ (RORγ) activity. This modulation has numerous effects, including inhibition of TH-17 cell function and/or TH-17 cell activity, and inhibition of re-stimulation of TH-17 cells, which are beneficial to treatment of inflammation and autoimmune disorders. Stimulation of RORγ results in stimulation of TH-17 cell function and/or activity which is beneficial for immune-enhancing compositions (e.g., vaccines).

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ORPHAGEN PHARMACEUTICALSSAN DIEGO CA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Babine, Robert Carlsbad, US 7 41
Li, Xiaolin San Diego, US 141 1247
Thacher, Scott San Diego, US 5 44
Tse, Bruno San Francisco, US 18 98

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