Scalable process for protein purification

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United States of America Patent

PATENT NO 9657065
APP PUB NO 20150315246A1
SERIAL NO

14596978

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Abstract

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The invention provides a process for the purification recombinantly expressed, self-assembled VLP from the homogenate of a bacterial host, wherein the process can be scaled up to a commercial production scale in a cost effective manner. The process comprises a first chromatography using an anion exchange matrix, a second chromatography using hydroxyapatite and, optionally, a size exclusion chromatography. VLP preparations obtained by the process of the invention are essentially free of endotoxin contaminations.

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Patent Owner(s)

Patent OwnerAddress
KUROS US LLC1209 ORANGE STREET CORPORATION TRUST CENTER WILMINGTON DE 19801

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Richter, Susanne Schlieren, CH 7 29
Topell, Simon Zurich, CH 5 9

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