Antibodies specific for sclerostin and methods for increasing bone mineralization

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United States of America Patent

PATENT NO 9657095
SERIAL NO

14662538

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Abstract

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Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.

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Patent Owner(s)

Patent OwnerAddress
UCB PHARMA S A1070 BRUSSELS

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Latham, John Seattle, US 106 3193
Shi, Jiye Rochester, US 21 285
Winkler, David G Arlington, US 40 1573

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