Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto

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United States of America Patent

PATENT NO 9663500
SERIAL NO

14659293

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Abstract

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Pyrazole derivatives of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (PAH) and related disorders; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack; angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; Crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (SLE); ulcerative colitis; ischemia-reperfusion injury; restenosis; atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (COPD).

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Patent Owner(s)

Patent OwnerAddress
ARENA PHARMACEUTICALS INC66 HUDSON BOULEVARD EAST NEW YORK NY 10001-2192

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ibarra, Jason B Las Vegas, US 15 95
Shin, Young-Jun San Diego, US 44 569
Tran, Thuy-Anh San Diego, US 49 354
Ullman, Brett San Diego, US 39 388
Zeng, Xi San Diego, US 44 140
Zou, Ning San Diego, US 38 245

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