Metal-particle-based oral-administrating liver-specific nucleic acid delivery system and method of manufacturing the same

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United States of America Patent

PATENT NO 9669103
APP PUB NO 20170065724A1
SERIAL NO

15074443

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Abstract

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Disclosed are a metal-nanoparticle-based liver-specific nucleic acid delivery system, a method of manufacturing the same, and a liver disease treatment composition containing the same. The liver-specific nucleic acid delivery system is coated with a bile acid-glycol chitosan polymer, so that it provides excellent liver-tissue specificity and high absorbance through digestive canals. Since the nucleic acid of the nucleic acid delivery system is coated with the bile acid-glycol chitosan polymer, it can be protected from decomposition of enzymes and the like inside a living organism. The liver-specific nucleic acid delivery system can be developed as an oral-administrating liver-disease treatment.

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Patent Owner(s)

Patent OwnerAddress
THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION(BANPO-DONG) THE CATHOLIC UNIVERSITY SEONGUI CAMPUS 222 BANPO-DAERO SEOCHO-GU SEOUL 06591 06591
KOREA NATIONAL UNIVERSITY OF TRANSPORTATION INDUSTRY-ACADEMIC COOPERATION FOUNDATION50 DAEHAK-RO DAESOWON-MYEON CHUNGJU-SI CHUNGCHEONGBUK-DO 27469 27469

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cho, Kwang Jae Seoul, KR 3 66
Kang, Sung Hoon Chungcheongbuk-do, KR 36 388
Lee, Sang Joon Gwangju, KR 46 244
Lee, Yong Kyu Chungcheongbuk-do, KR 23 277
Nurunnabi, Mohammed Chungcheongbuk-do, KR 1 2
Park, In Kyu Gwangju, KR 55 462

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