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Abstract

The invention relates to oligonucleotide-oligocation molecules A_iB_jH that can be synthetized via automated phosphoramidite chemistry having oligonucleotides moieties Ai and oligocations moieties Bj, wherein .A_i is an i-mer oligonucleotide residue, with i=5 to 50, where nucleotide A is an oligomer with naturally or non naturally occurring nucleobases and/or pentafuranosyl groups and/or native phosphodiester bonds, for example selected from the group comprising deoxyribo, ribo, locked (LNA) nucleotides as well as their chemical modifications or substitutions such as phosphorothioate, 2′-fluoro, 2′-O-alkyl, or a marker group such as a fluorescent agent, .Bj is a j-mer organic oligocation moiety, with j=1 to 50, where B is selected from the group comprising .—HPO₃—R¹—(X—R²_n)_n1—X—R³—O—, where R¹, R²n and R³, identical or different, are lower alkylene, X is NH or NC(NH₂)₂, n varies from 1 to 5 and n1=2 to 20, .—HPO₃—R⁴—CH(R⁵X¹)—R⁶—O—, where R⁴ is lower alkylene, R⁵ and R⁶, identical or different, are lower alkylene and X¹ is putrescine, spermidine or spermine residue, .—HPO₃—R⁷-(aa)_n2-R⁸—O—, where R⁷ is lower alkylene and R⁸ is lower alkylene, serine, a natural aminoalcohol, (aa)_n2 is a peptide containing natural aminoacids with cationic side chains, such as Arginine, Lysine, Ornithine, -Histidine, Diaminopropionic acid and n2=2 to 20.

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First Claim