Composition and method for diversification of target sequences

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United States of America Patent

PATENT NO 9677070
APP PUB NO 20130261012A1
SERIAL NO

13802255

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Abstract

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The disclosure relates generally to the targeting of genes to, and their integration into, an immunoglobulin (antibody) heavy chain locus. In particular, the methods described herein contemplate replacing the single rearranged heavy chain V, D, and J genes of a B cell lymphoma such as DT40 with independently rearranged VH-D-JH genes of chicken, in a system for generating immunoglobulin diversity. Also contemplated is replacement of the chicken VH-D-JH with rearranged VH-D-JH genes of other vertebrates including human in a system for generating immunoglobulin diversity, with the exception of any substitution disclosed and claimed in PCT application WO 2009/029315 A2. Also described is construction of a diverse chicken immunoglobulin heavy chain VDJ library in DT40 by homologous gene replacement of the single endogenous rearranged VDJ gene with a chicken VDJ repertoire using the described targeting vectors.

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Patent Owner(s)

Patent OwnerAddress
WILMINGTON SAVINGS FUND SOCIETY FSB AS COLLATERAL AGENT500 DELAWARE AVENUE 11TH FLOOR WILMINGTON DE 19801

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Allison, Daniel S Lake Forest Park, US 43 274
Cummings, W Jason Bellevue, US 17 55
Leppard, John B Mukilteo, US 3 23
Maizels, Nancy Seattle, US 11 117
Tjoelker, Larry W Kirkland, US 32 186
Wood, Christi L Snohomish, US 11 29
Yabuki, Munehisa Seattle, US 22 55

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