Peptide C alpha-amides, methods for preparing same and uses thereof as precursors of peptide C alpha-thioesters for protein synthesis
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United States of America Patent
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Jun 20, 2017
Grant Date -
Jan 15, 2015
app pub date -
Dec 21, 2012
filing date -
Jan 3, 2012
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Abstract
The subject matter of the present invention is peptide Cα-amides which are precursors of peptide Cα-thioesters, characterized in that they comprise the radical of general formula (I) in which X, R1, R2, R3, R4, R5, R6, R7, R8, R9, n and A are as defined in Claim 1. The subject matter of the present invention is also the use of these peptide Cα-amides for obtaining peptide Cα-thioesters. The subject matter of the present invention is also the use of these peptide Cα-amides for obtaining peptides or proteins, in particular of therapeutic interest, by direct use as a crypto-thioester partner in NCL reactions.
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