Anti-leukocyte adhesion for the mitigation of potential adverse events caused by CD3-specific binding domains

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United States of America Patent

PATENT NO 9688760
SERIAL NO

14176091

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Abstract

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The present invention relates in essence to use of a compound, which decreases or inhibits the binding of mammalian T-cells to mammalian endothelial cells for use in a method of prophylaxis and/or amelioration and/or treatment of clinical adverse events caused by a therapy which comprises re-directing of T-cells against target cells in a patient. Such a therapy includes, but is not limited to, treatment with an antibody comprising a CD3 binding domain, such as a CD20×CD3 or a CD19×CD3 bispecific single chain antibody, e.g., blinatumomab (MT-103). Methods of treatment of patients having or being at risk of clinical adverse events caused by therapy which comprises re-directing of T-cells against target cells are also contemplated, as are methods of identifying a compound for administration in the methods of prophylaxis, amelioration and/or treatment. Such anti-adhesive type compounds include, but are not limited to, antibodies, like natalizumab, efalizumab, and etrolizumab; minocycline, (acetyl-)salicyclic acid, astilbin, and flavonoids; and thrombin and pentosanpolysulfate (PPS), or a pharmaceutically acceptable salt thereof.

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Patent Owner(s)

Patent OwnerAddress
AMGEN RESEARCH (MUNICH) GMBH81477 MÜNCHEN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dopfer, Elaine-Pashupati Munich, DE 4 41
Hoffmann, Patrick Bad Heilbrunn, DE 69 1097
Klinger, Matthias Gilching, DE 27 546
Kufer, Peter Munich, DE 106 2671
Naegele, Virginie Munich, DE 5 17
Nagorsen, Dirk Munich, DE 16 72
Scheele, Juergen Munich, DE 22 132
Zugmaier, Gerhard Munich, DE 21 209

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