3′-OH unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing
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United States of America Patent
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Jun 27, 2017
Grant Date -
Dec 22, 2016
app pub date -
Jun 21, 2016
filing date -
Sep 13, 2011
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Abstract
The present invention relates generally to 3′-OH unblocked nucleotides and nucleosides labeled and unlabeled with 5-methoxy-substituted nitrobenzyl-based photocleavable terminating groups for use in methods and systems related to DNA and RNA sequencing and analysis. These compounds may be used as reversible terminators as they exhibit fast nucleotide incorporation kinetics, single-base termination, high nucleotide selectivity, and rapid terminating group cleavage that results in a naturally occurring nucleotide.
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