Oligooxopiperazines for p53 reactivation

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United States of America Patent

PATENT NO 9695153
SERIAL NO

14160037

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Abstract

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The present invention relates to oligooxopiperazines for reactivating p53. The oligooxopiperazines comprise two or three oxopiperazine rings and substantially mimic helix αB of the C-terminal transactivation domain of Hypoxia-Inducible Factor 1α. Methods of using the oligooxopiperazines are also disclosed. Exemplary oligooxopiperazines include those of Formula I below (wherein A, R1, R2, R3, R4, and B are as defined herein).

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THE REGENTS OF THE UNIVERSITY OF MICHIGAN1600 HURON PARKWAY 2ND FLOOR ANN ARBOR MI 48109

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Arora, Paramjit S Cold Spring Harbor, US 28 143
Mapp, Anna Ann Arbor, US 5 6
Pan, Quintin Dublin, US 5 6

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