C1-phostphonate analogue of UDP-GlcNAc for inhibition of O-GlcNAc transferase
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United States of America Patent
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Jul 4, 2017
Grant Date -
Jan 26, 2017
app pub date -
Dec 15, 2015
filing date -
Jul 20, 2015
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Abstract
A novel C1-phosphate log of uridine-5′-diphosphate (UDP)-GlcNAc as an effective OGT (O-linked N-acetylglucosamine (O-GlcNAc) transferase) inhibitor, and a preparation method for the same provides a compound having an OGT inhibitory effect that can be used as a useful tool in the studies on various vital phenomena in association with the protein modification by O-GlcNAc within cells and furthermore as a candidate substance in the treatment or research of diseases related to the protein modification by O-GlcNAc, such as cancers, diabetes, or degenerative neurological diseases.
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