Pharmaceutical composition for preventing or treating ocular surface disease
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United States of America Patent
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Jul 4, 2017
Grant Date -
Jul 28, 2016
app pub date -
Dec 27, 2015
filing date -
Dec 26, 2014
priority date (Note) -
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Abstract
A pharmaceutical composition for preventing or treating an ocular surface disease is disclosed, wherein the pharmaceutical composition includes, as an active component, collagen type II α1 based peptide SEQ ID NO: 2 isolated from chondrocyte-derived extracellular matrix (CDEM). In an alkaline burn animal mode treated with peptide SEQ ID NO: 2, the occurrence of corneal opacification is reduced as well as the expression of angiogenic factors. In addition, the expression of inflammatory markers is reduced while the expression of inflammation-inducing factor is suppressed. The peptide SEQ ID NO: 2 may be applied to a pharmaceutical composition for preventing or treating an ocular surface disease.
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