Polynucleotides comprising a reporter sequence operatively linked to a regulatory element

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United States of America Patent

PATENT NO 9695481
SERIAL NO

13823661

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Abstract

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The invention provides a polynucleotide comprising a reporter sequence operatively linked to a regulatory element of a gene selected from Bscl2, Srxnl, Cbr3, Ephxl, Nope, Cdknla, Perp, Pltp, Cgrefl, Ltb4r1, Btg2, Gpx2, Ltb4r2, Ddit4l, Fosl1, and Egr1, which regulatory element stimulates expression of the reporter sequence in response to a genotoxic agent or to an oxidative stress-inducing agent. The invention also provides a method of detecting a genotoxic or oxidative stress-inducing agent comprising subjecting a cell containing the polynucleotide of the invention to a test agent; and assessing the expression of the reporter sequence. The invention provides a method of detecting a genotoxic or oxidative stress-inducing agent comprising subjecting one or more cells that comprise a reporter sequence operatively linked to a regulatory element of a gene, which regulatory element stimulates expression of the reporter sequence in response to a genotoxic agent or to an oxidative stress-inducing agent, to a test agent, and assessing the expression of the one or more reporter sequences; wherein at least one cell subjected to a test agent comprises a polynucleotide comprising a reporter sequence operatively linked to a regulatory element of the Bscl2 gene.

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Patent Owner(s)

Patent OwnerAddress
ACADEMISCH ZIEKENHUIS LEIDEN ALSO ACTING UNDER LEIDEN UNIVERSITY MEDICAL CENTER (LUMC)ALBINUSDREFF 2 LEIDEN NL-2333

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Van, de Water Bob Leiden, NL 1 1
Vrieling, Harm Leiden, NL 1 1

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