Method of preparing oligomeric compounds using modified coupling protocols
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United States of America Patent
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Jul 11, 2017
Grant Date -
Dec 24, 2015
app pub date -
Jan 30, 2014
filing date -
Jan 31, 2013
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Abstract
Provided herein are methods for the synthesis of oligomeric compounds wherein the standard coupling protocols are modified when coupling bicyclic nucleosides of Formula I. More particularly, the modified coupling protocols provide for a decrease in the ratio of phosphoramidite solution to activator solution in the coupling reagent with an increased contact time. The modified coupling protocols provide for oligomeric compounds having comparable yields to similar oligomeric compounds having modified nucleosides other than bicyclic nucleosides of Formula I.
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