Biological indicator

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United States of America Patent

PATENT NO 9701968
SERIAL NO

15204124

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Abstract

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This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for producing an indicator enzyme; a regulatory gene; and a vehicle for inserting the reporter gene and the regulatory gene in the host organism; the host organism bearing a transposable genetic element in its genome for inserting an insertion sequence in the regulatory gene; the insertion sequence comprising a transposase, a pair of terminal inverted repeat sequences, and at least one open reading frame for expressing the transposase. The vehicle may be taken up by the host organism. The insertion sequence may be inserted in the regulatory gene. The host organism may undergo sporulation to form the biological indicator. A process and an apparatus for using the biological indicator are disclosed.

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Patent Owner(s)

Patent OwnerAddress
AMERICAN STERILIZER COMPANY5960 HEISLEY ROAD MENTOR OH 44060 UNITED STATES OF AMERICA

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Burke, Peter A Concord, US 133 2042
Cregger, Tricia A Fairlawn, US 33 207
Franciskovich, Phillip P Concord, US 54 282
Yirava, William A Willoughby, US 17 62

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