Methods for sequencing a biomolecule by detecting relative positions of hybridized probes

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United States of America Patent

PATENT NO 9702003
APP PUB NO 20150045235A1
SERIAL NO

14468959

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A sequencing method is presented in which a biomolecule is hybridized with a specially chosen pool of different probes of known sequence which can be electrically distinguished. The different probe types are tagged such that they can be distinguished from each other in a Hybridization Assisted Nanopore Sequencing (HANS) detection system, and their relative positions on the biomolecule can be determined as the biomolecule passes through a pore or channel. The methods eliminate, resolve, or greatly reduce ambiguities encountered in previous sequencing methods.

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Patent Owner(s)

  • HEALTHCARE FINANCIAL SOLUTIONS, LLC, AS AGENT (SUCCESSOR - IN - INTEREST TO GENERAL ELECTRIC CAPITAL CORP., AS AGENT)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Goldstein, Peter H Providence, US 2 36

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