Process for the specific isotopic labeling of methyl groups of Val, Leu and Ile

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United States of America Patent

PATENT NO 9708228
APP PUB NO 20130122598A1
SERIAL NO

13520882

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Abstract

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The invention relates to a process for the specific isotopic labeling of Valine, Leucine and Isoleucine amino acids. The process of the invention uses a 2-alkyl-2-hydroxy-3-oxobutanoic acid in which the alkyl substituent in position 2 is ethyl or methyl. The invention can be used for the analysis of proteins, in particular by NMR.

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Patent Owner(s)

Patent OwnerAddress
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE3 RUE MICHEL ANGE PARIS 75016
UNIVERSITE JOSEPH FOURIER38041 GRENOBLE CEDEX 9
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVESBAT LE PONANT 25 RUE LEBLANC PARIS 75015

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ayala, Isabel Pont de Claix, FR 2 1
Boisbouvier, Jérôme Grenoble, FR 2 0
Gans, Pierre Voreppe, FR 3 1
Hamelin, Olivier Champagnier, FR 2 1

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